Publications

Selected Publications

Complete list of publications can be found at scholar.google.com, Pubmed or Researchgate.

  1. Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
    Wirjanata G., Lin J., Dziekan J.M., El Sahili A., Chung Z., …, Lescar J., Bozdech Z. (2024). Cell Chemical Biology. Apr 18;31(4):743-759.e8.
  2. Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV00848.
    Chung, Z., Lin, J., Wirjanata, G., Dziekan, J. M., El Sahili, A., Preiser, P. R., Bozdech, Z., & Lescar, J. (2023).  Journal of Biological Chemistry 300, 105586
  3. On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation. 
    Chua, N., Wong, Y.H., El Sahili, A., Liu, C.F. and Lescar, J. (2023).FEBS Open Bio, 13: 1095-1106.
  4. Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
    Ku, Z., Xie, X., Lin, J., Gao, P., Wu, B., El Sahili, …, Lescar, J., Shi, P.Y., An, Z. (2022). Nature Communications 2022 13:1, 13(1), 1–12. 

  5. The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.
    Poh, Wee-Han & Lin, Jianqing & Colley, Brendan & Müller, Nicolai & Goh, Boon Chong & Schleheck, David & El Sahili, Abbas & Marquardt, &reas & Liang, Yang & Kjelleberg, Staffan & Lescar, Julien & Rice, Scott A. & Klebensberger, Janosch. (2020). PLOS ONE 15(11): e0241019. https://doi.org/10.1371/journal.pone.0241019

  6. Two RNA tunnel inhibitors bind in highly conserved sites in Dengue virus NS5 polymerase: structural and functional studies
    Arora, Rishi & Liew, Chong Wai & Soh, Tingjin Sherryl & Otoo, Dorcas Adobea & Seh, Cheah Chen & Yue, Kimberley & Nilar, Shahul & Wang, Gang & Yokokawa, Fumiaki & Noble, Christian G. & Chen, Yen Liang & Shi, Pei-Yong & Lescar, Julien & Smith, Thomas M. & Benson, Timothy E. & Lim, Siew Pheng. (2020) Journal of Virology. JVI.01130-20; DOI: 10.1128/JVI.01130-20

  7. Crystal structure of the periplasmic sensor domain of histidine kinase VbrK suggests indirect sensing of β-lactam antibiotics.
    Goh, Boon Chong & Chua, Yong & Qian, Xinlei & Lin, Jianqing & Savko, Martin & Dedon, Peter & Lescar, Julien. (2020).  Journal of structural biology. 107610. 10.1016/j.jsb.2020.107610.
  8. Non-Nucleoside Inhibitors of Zika virus RNA-dependent RNA polymerase.
    Gharbi-Ayachi, Aicha & Santhanakrishnan, Sridhar & Wong, YeeHwa & Chan, Kitti & Tan, Siok & Bates, Roderick & Vasudevan, Subhash & El Sahili, Abbas & Lescar, Julien. (2020).  Journal of Virology. 10.1128/JVI.00794-20.
  9. Structure of the human metapneumovirus polymerase phosphoprotein complex.
    Pan, Junhua & Qian, Xinlei & Lattmann, Simon & El Sahili, Abbas & Yeo, Tiong & Jia, Huan & Cressey, Tessa & Ludeke, Barbara & Noton, Sarah & Kalocsay, Marian & Fearns, Rachel & Lescar, Julien. (2020).  Nature. 577. 10.1038/s41586-019-1759-1.
  10. NS5 from Dengue virus serotype 2 can adopt a conformation analogous to its ZIKV and JEV homologues.
    El Sahili, Abbas & Soh, Tingjin & Schiltz, Jonas & Gharbi-Ayachi, Aïcha & Seh, Cheah & Shi, Pei-Yong & Lim, Siew & Lescar, Julien. (2019).  Journal of Virology. 94. 10.1128/JVI.01294-19.
  11. Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N 1 )-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
    Zhong, Wenhe & Pasunooti, Kalyan & Balamkundu, Seetharamsingh & Wong, YeeHwa & Nah, QianHui & Gadi, Vinod & Gnanakalai, Shanmugavel & Chionh, Yok & Mcbee, Megan & Gopal, Pooja & Lim, Siau & Olivier, Nelson & Buurman, Ed & Dick, Thomas & Liu, Chuan-Fa & Lescar, Julien & Dedon, Peter. (2019).  Journal of Medicinal Chemistry. 62. 10.1021/acs.jmedchem.9b00582.
  12. Crystal structure and catalytic mechanism of the essential m 1 G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa.
    Jaroensuk, Juthamas & Wong, YeeHwa & Zhong, Wenhe & Liew, Chong & Maenpuen, Somchart & El Sahili, Abbas & Atichartpongkul, Sopapan & Chionh, Yok & Nah, Qianhui & Thongdee, Narumon & Mcbee, Megan & Prestwich, Erin & DeMott, Michael & Chaiyen, Pimchai & Mongkolsuk, Skorn & Dedon, Peter & Lescar, Julien & Fuangthong, Mayuree. (2019).  RNA. 25. rna.066746.118. 10.1261/rna.066746.118.
  13. Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.
    Zhong, Wenhe & Guo, Jingjing & Cui, Liang & Chionh, Yok & Li, Kuohan & El Sahili, Abbas & Cai, Qixu & Yuan, Meng & Michels, Paul & Fothergill-Gilmore, Linda & Walkinshaw, Malcolm & Mu, Yuguang & Lescar, Julien & Dedon, Peter. (2019). Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis. Journal of Molecular Biology. 431. 10.1016/j.jmb.2019.07.033.
  14. Structural determinants for peptide-bond formation by asparaginyl ligases.
    Hemu, Xinya & El Sahili, Abbas & Hu, Side & Wong, Kaho & Yu, Chen & Wong, YeeHwa & Zhang, Xiaohong & Serra, Aida & Goh, Boon Chong & Darwis, Dina & Chen, Ming & Sze, Siu & Liu, Chuan-Fa & Lescar, Julien & Tam, James. (2019).  Proceedings of the National Academy of Sciences. 116. 201818568. 10.1073/pnas.1818568116.
  15. Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.
    Dai, Liang & Lin, Jianqing & Said, Aminahtusaidah & Yau, Yin Hoe & Geifman, Susana & Ruiz-Carrillo, David & Sun, Kang & Chandrasekaran, Ramya & Sze, Siu & Lescar, Julien & Cheung, Peter. (2019).  Biochemical and Biophysical Research Communications. 513. 10.1016/j.bbrc.2019.03.095.
  16. The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition.
    Ruiz-Carrillo, David & Lin, Jianqing & El Sahili, Abbas & Wei, Meng & Sze, Siu & Cheung, Peter & Doerig, Christian & Lescar, Julien. (2018).  Scientific Reports. 8. 10.1038/s41598-018-25738-5.
  17. Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513.
    Wong, YeeHwa & Kumar, Akshita & Liew, Chong & Tharakaraman, Kannan & Srinivasaraghavan, Kannan & Sasisekharan, Ram & Verma, Chandra & Lescar, Julien. (2018). Scientific Reports. 8. 10.1038/s41598-018-26800-y.
  18. Insights into biofilm dispersal regulation from the crystal structure of the PAS-GGDEF-EAL region of RbdA from Pseudomonas aeruginosa.
    Liu, Chong & Liew, Chong & Wong, YeeHwa & Tan, Siok & Poh, Wee Han & Manimekalai, Malathy & Rajan, Sreekanth & Xin, Lingyi & Liang, Zhao-Xun & Grüber, Gerhard & Rice, Scott & Lescar, Julien. (2017).  Journal of Bacteriology. 200. JB.00515-17. 10.1128/JB.00515-17.
  19. Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex.
    Yee Hwa Wong, Boon Chong Goh, She Yah Lim, En Wei Teo, Angeline P. C. Lim, Pete C. Dedon, Brendon J. Hanson, Paul A. MacAry, Julien Lescar. Journal of Virology, 91(17):JVI.00406-17, 2017
  20. Dengue Virus Non-Structural Protein 5
    Abbas El Sahili, Julien Lescar. Viruses, 9(4):91, 2017
  21. Engineering a Catalytically Efficient Recombinant Protein Ligase.
    Renliang Yang, Yee Hwa Wong, Giang K T Nguyen, James P Tam, Julien Lescar, Bin Wu. Journal of the American Chemical Society, 139(15):5351–5358, 2017
  22. Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope.
    Luke N. Robinson, Kannan Tharakaraman, …, Yee Hwa Wong, … , Julien Lescar, Zachary Shriver, Eng Eong Ooi, Ram Sasisekharan. Cell, 162:493-502, 2015
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